Division of Molecular and Cellular Biosciences Core Programs

MCB supports research that promises to uncover the fundamental properties of living systems across atomic, molecular, subcellular, and cellular scales. The program gives high priority to projects that advance mechanistic understanding of the structure, function, and evolution of molecular, subcellular, and cellular systems, especially research that aims at quantitative and predictive knowledge of complex behavior and emergent properties. MCB encourages research exploring new concepts in molecular and cellular biology, while incorporating insights and approaches from other scientific disciplines, such as chemistry, computer science, engineering, mathematics, and physics, to illuminate principles that govern life at the molecular and cellular level. MCB also encourages research that exploits experimental and theoretical approaches and utilizes a diverse spectrum of model and non-model animals, plants, and microbes across the tree of life. Proposals that pursue potentially transformative ideas are welcome, even if these entail higher risk. This solicitation calls for proposals in research areas supported by the four MCB core clusters, including: (i) structure, dynamics, and function of biomolecules and supramolecular assemblies, especially under physiological conditions ( Molecular Biophysics); (ii) organization, processing, expression, regulation, and evolution of genetic and epigenetic information ( Genetic Mechanisms); (iii) cellular structure, properties, and function across broad spatiotemporal scales ( Cellular Dynamics and Function); and (iv) systems and/or synthetic biology to study complex interactions through modeling or manipulation or design of living systems at the molecular-to-cellular scale ( Systems and Synthetic Biology). All MCB clusters prioritize projects that integrate across scales, investigate molecular and cellular evolution, synergize experimental research with computational or mathematical modeling, and/or develop innovative, broadly applicab